5-HYDROXYTRYPTOPHAN

Theoretically, 5–hydroxytryptophan (5-HTP) could contribute towards serotonin syndrome, a very rare condition associated with confusion, restlessness, and shivering/tremor/twitching. This warning came about because high-doses of parenteral (injected into the abdomen) 5-HTP can cause acute serotonin syndrome in rats. However, in humans, 5-HTP has never been clinically associated with serotonin syndrome. The full dose of CalmNeeds® includes 200 mg of 5-HTP. According to the US National Institute of Health TOXNET, 5-HTP has not been associated with serotonin syndrome or, based on many studies, any serious adverse events in humans. Severe serotonin syndrome is rare in humans (but common in rodents), and almost exclusively caused by an SSRI (selective serotonin reuptake inhibitor, e.g. citalopram, fluoxetine, sertraline) or an SNRI (serotonin-norepinephrine reuptake inhibitor, e.g. duloxetine, venlafaxine) coupled with an MAOI (monoamine oxide inhibitor, e.g. isocarboxazid, phenelzine) [PMID: 27692695]. MAOI drugs are rarely prescribed today. Because serotonin syndrome may be more likely if one is also taking certain antidepressants, consult with your physician before taking CalmNeeds® if you are taking one of these classes of drugs, or if you are uncertain which class of drugs you are taking.

5-Hydroxytryptophan is usually referred to by its abbreviation 5-HTP, which is how it will be referred to herein. It is a naturally-occurring non-protein amino acid found in many foods, but in low amounts. Higher amounts of 5-HTP is found in the seeds of the plant Griffonia simplicifolia, which is used as an herbal supplement.

5-HTP is an intermediate between the amino acid tryptophan, from which it is made, and serotonin, an important neurotransmitter in the nervous system, including the brain and gut. Conversion of 5-HTP to serotonin (5-hydroxytryptamine, 5-HT) is by the enzyme aromatic-L-amino-acid decarboxylase, and requires the active vitamin B6 cofactor PLP.

5-HTP is made by our bodies and not a required part of the diet.

Common uses are for supporting emotional well-being, mood, sleep, and appetite suppression*.

Potential side effects of 5-HTP include heartburn, nausea, gas, vomiting, diarrhea, drowsiness, and vivid dreams or nightmares. Side effects are rare at usual doses used in supplementation. However, the full dose of CalmNeeds® (2 capsules = 200 mg 5-HTP at one time) may cause side effects in some sensitive people, which is one reason for the recommendation to start at one capsule and increase as needed and tolerated.

Laboratory testing is not likely to be of clinical utility

5-HTP is added to CalmNeeds® due to its potential effects against over-activity, irritability and to promote sleep*.

*These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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