Cyclic vomiting syndrome (CVS) is a functional disorder defined by well-defined episodes of nausea, vomiting, and lethargy (tiredness).

What distinguishes CVS from other disorders is
that in CVS the episodes are:

  • Multiple: They keep happening.

  • Stereotypical: Episodes are all similar to each other.

  • Distinct: Nausea and vomiting are much reduced or absent between episodes.

Dr. Richard Boles posing in front of a tree

Dr. Richard Boles

“Cyclic Vomiting is a functional disorder due to the function of the cells, tissues, and organs; not their structure. So you can do an MRI, you can do an upper GI, you can do an ultrasound, and you will probably not find anything.

It doesn’t mean that it’s not real or in the head or not important.”

Read Recent CVS Research

Read more about Dr. Boles


The research shows a strong correlation between mitochondrial dysfunction and CVS. This leads to some startling conclusions about cyclic vomiting syndrome treatment in adults and children.

To see the abstracts (summaries) of Dr. Richard G. Boles’ articles regarding CVS

Many of these studies demonstrate a degree of mitochondrial dysfunction in CVS. Based upon this work, it was shown that most patients with CVS have some degree of mitochondrial dysfunction. This work is important because it suggests that mitochondrial-targeted therapies might be helpful in many
(likely most) people with CVS. 

There are no tests for CVS, but there is a nutritional cocktail demonstrated to help adults and children experiencing chronic nausea.

YouTube icon