Niacin (also known as vitamin B3, one form of which is niacinamide)
Niacin in EnergyNeeds®
Niacin in the form of niacinamide is added in order to provide a wide basis of nutrition, especially given the important role of niacin/niacinamide in energy metabolism. Side effects are unexpected.
What Is Niacin?
Niacin, also known as vitamin B3, is one of the eight B-complex vitamins. Niacin cannot be manufactured by humans and is thus a true vitamin, obtained exclusively from the diet.
What Does Niacin Do?
Niacin is a precursor of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are required for a very large number of enzymes in essentially all metabolic pathways, including central roles in energy metabolism.
What Does a Niacin Deficiency Appear As?
Deficiency is rare, and generally found in individuals with highly-restricted diets and/or substantial gastrointestinal disease. Symptoms can include nausea, skin and mouth lesions, anemia, diarrhea, headaches, mental confusion, and tiredness.
What About Niacin‘s Use in Disease?
Niacin is important for maintaining a healthy cardiovascular system and metabolism, especially balancing blood cholesterol levels. In addition, niacin helps with brain function, healthy skin formation, and the maintenance of normal blood sugar.
What Are the Common and/or Important Side Effects Niacin?
Niacin is water-soluble vitamin and thus considered to be generally non-toxic. Niacin in the form of nicotinic acid is well known for causing flushing, but it is harmless. The niacinamide (also known as nicotinamide) form of niacin does not cause a flush, but also is not effective in lowering cholesterol levels. Side effects are rare at usual doses of niacinamide used in supplementation.
Is There Any Laboratory Testing for a Niacin Deficiency?
Laboratory testing can reveal the presence of a deficiency of this nutrient, but is generally not likely to have clinically utility.