By:  Richard G. Boles, M.D.


CalmNeeds® is a nutritional intervention designed to address behavioral over-activity, which is generally treated by medications for individuals with anxiety, ADHD, mood swings, and other neuro-developmental disorders.  Prescription medications are not the only treatments available. In particular, nutritional supplements are often recommended for individuals with various forms of behavioral over-activity. CalmNeeds® offers a unique and natural path to calmness, day or night.  This formula contains a combination of Vitamins B6, magnesium, L-theanine, 5-HTP, and GABA designed to:

• Relieve stress and anxious mood*

• Promote sleep and relaxation*

• Support a calm and positive mood*

• Ease tension and physical discomfort*

• Diminish overactive nerve conduction*

• Assist in serotonin production*

The science behind being calm is that it is healthier for our minds and bodies to be calm.  Research at Johns Hopkins Medical School revealed that “People who feel angry often and fail to deal with it well are more likely to have heart problems…; the more intense or frequent the blow-ups, the higher one’s heart risks.” Why?  Anger causes the body to produce stress hormones known as catecholamines, which increase our blood pressure and “play a role in the development of artery clogging plaque….”.

Emory University Medical School researchers have concluded that stress “can activate cytokine molecules causing inflammation….  and behavioral responses to stress, both of which are linked to serious illnesses including cancer and heart disease”.  

A recent article in Scientific American notes, “But our fight-or-flight response places extreme demands on the mitochondria. All of a sudden, they need to produce much more energy to fuel a faster heartbeat, expanding lungs and tensing muscles, which leaves them vulnerable to damage. Unlike DNA in the cell’s nucleus, though, mitochondria have limited repair mechanisms.” And recent animal studies have shown chronic stress can lead only to mitochondrial damage in brain regions such as the hippocampus, hypothalamus and cortex.  (Accessed from the internet on 11/10/2020)


Nerve cells, or neurons, do not touch each other, but are separated by a gap called the synapse. Chemicals called neurotransmitters travel from one neuron to the next to bridge this gap. Some neurotransmitters are excitatory, which result in increased neuronal function, while other neurons are inhibitory, which result in decreased neuronal function. While the function of the nervous system, including the brain, is extremely complicated, one important aspect is the balance between excitatory and inhibitory neurotransmitters. When this balance is off, and a hyper-excitable state is present, providing substances that support inhibitory neurotransmission can often help re-establish the balance. CalmNeeds® contains five active ingredients designed to do just that. These ingredients are often taken together, and likely have a synergistic calming effect.

Moreover there are health benefits to being calm.


MAGNESIUM is required for the function of over 300 enzymatic reactions, including in energy metabolism where it plays a pivoted role. Magnesium is also required for the synthesis of fatty acids and proteins, proper insulin response, and the transmission of nerve impulses. Learn more about Magnesium: 

PYRIDOXINE, otherwise known as B6, cannot be manufactured by humans and is obtained exclusively from the diet.  In particular, PLP is the cofactor for the enzymes that synthesize GABA and serotonin, both of which are neurotransmitters with key inhibitory roles. disease.  Learn more about Pyridoxine: 

GABA, (gamma-aminobutyric acid), is the main inhibitory neurotransmitter in the central nervous system. GABA reduces neuronal excitability throughout the nervous system.  Learn more about Gaba: 

L-THEANINE is present in many plants commonly ingested and is a principal component of the effects of green and black tea. L-theanine has been demonstrated to increase the levels of several neurotransmitters, including GABA, glycine, serotonin, and dopamine. Learn more about L-Theanine:

5-HTP is a naturally-occurring substance that is an intermediate between the amino acid tryptophan and serotonin, an important neurotransmitter in the nervous system.  Learn more about 5-HTP:

For any additional questions regarding CalmNeeds®, please visit or email   

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This information is neither a full disclosure of all relevant information nor an academic text. In particular, nutrients are used frequently by others in the treatment of a variety of conditions, some with little to no scientific backing, and inclusion in the section entitled What About [This Ingredient’s] Use in Disease? does NOT reflect a recommendation or endorsement. Additionally, this site does not include all side effects reported. Please consult your physician and/or seek additional sources as appropriate.

The Content within this article and NeuroNews Blog is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this Blog.

Disclosure: Dr. Boles is the Chief Medical & Scientific Officer for NeuroNeeds LLC, the start-up company that makes SpectrumNeeds®, EnergyNeeds®, QNeeds®, and CalmNeeds®. As such, he may receive financial compensation based upon by efforts and/or the success of the company. You are under no obligation to purchase these or any products, whether recommended by Dr. Boles or another health care provider. As always, it is recommended that you contact your physician regarding these products and all other changes to disease management.